One day, Duncan is happily coloring with his crayons when a stack of postcards arrives in the mail from his former crayons, each of which has run away or been left behind, and all of which want to come home.
Mrs. LaRue takes a cross-country drive with her hospitalized neighbor's cats and her own dog, Ike, who keeps the cats' owner informed of their misadventures through a series of postcards.