Kitty's owners are taking a week off and leaving Kitty and Puppy at home with Uncle Murray. It isn't long before Uncle Murray is driven to near madness by shenanigans of epic proportions.
After Karen's best friend Hannie gets a kitten, Karen wants to start a Kittycat Club for all of her friends with cats. Emulating her older sister Kristy, she decides to open up the club to cat-sitting.
Twelve-year-old Katie now knows her neighbor Madeline is also the Mousetress, the city's most feared villain (or most misunderstood superhero), and she is ready to become the super sidekick she always wanted to be.
In Dorset, England, twelve-year-old Kat Wolfe opens a pet-sitting business, but the owner of her first client goes missing and only her new friend shares Kat's conviction that the parrot's owner is the victim of foul play.