Will Graham is an FBI agent who brought Hannibal Lecter to justice; however, his confrontation with Lecter proved to be a bloody, near-death experience. Retiring from the Bureau, he moves to Florida. However, a particularly grisly killer is on the loose, and Jack, Graham's one-time mentor at the Bureau, asks him to return to duty to find him. "The Tooth Fairy" is a vicious murderer who kills entire families at once, covering the eyes of his victims...

When FBI agent Clarice Starling is assigned a case involving a monstrous serial killer, she seeks counsel from an imprisoned cannibalistic psychiatrist Dr. Hannibal Lecter, whose fascination with the young woman is as great as his hunger for murder. As their relationship develops, Starling must confront her own demons, and an evil so powerful that she may not have the courage or strength to stop it.

After young Hannibal is forced to watch his little sister, Mischa, being devoured by starving soldiers in his Lithuania homeland. Hannibal vows to avenge his sister's death by slaying those who committed not only war crimes against the Lecters, but also against other families during WW II. Hannibal's revenge plan includes his cannibalism to justify his insatiable appetite for human flesh. Hannibal excels in his medical school classes dissecting cadavers....