David Sadava
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What do population studies tell us about the causes of cancer? Define the science of epidemiology and learn how it can be used to study cancer in both populations and individuals. Differentiate between case-control and cohort studies, and the categories of risk factors for cancer.
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Explore avenues of treatment at the frontiers of science, starting with how a patient's own immune system can be harnessed in cancer therapy. Take an in-depth look at antibodies and gene therapy as options for treatment and consider the amazing potential of viruses that target tumors only and leave normal cells undamaged.
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The body does everything it can to reject a tumor, but sometimes the immune system is not only too overburdened to succeed, it's unable to even recognize that tumors exist. Find out why tumors can go undetected as you continue your investigation of metastasis and angiogenesis, and how these phenomena contribute to the growth and spread of tumors.
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Why are monthly breast self-examinations no longer recommended in some countries? Do PSA screenings for prostate cancer have any impact on survival rates for men with the disease? Examine the science of screening and the success rates of current screening methods and consider whether getting screened is worthwhile given the risks and costs associated with each.
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Why do cancers sometimes run in families? Explore the "two-hit" hypothesis for how cancers are inherited along with the criteria for defining cancer as hereditary with a discussion of several forms - including retinoblastoma, colon cancer, and breast cancer - that are known to be passed on this way. Explore inherited susceptibilities to cancer that make people prone to developing this disease.
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All tumors are not created equal. Trace how cancer develops as a series of molecular changes, then learn how the worldwide Cancer Genome Project is working toward individualized therapies. Conclude by looking at genetic testing and considering its ethical and legal ramifications.
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Continue your investigation of ways to treat cancer by learning how radiation treatments, including proton therapy, brachytherapy, and radiosurgery, are often used to kill cancer cells. Next, explore the use of stem cell transplantation to restore the bone marrow of patients who've experienced high doses of radiation or chemotherapy.
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Take the first steps in understanding the multistage model of cancer by learning how various agents initiate cancer at the genetic level. Explore the fundamentals of DNA as genetic material, the process by which DNA is expressed and duplicated, and the ways this process of duplication can go awry, causing cell mutations to accumulate.
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How do tumors start? Find out how cells divide without normal controls in place and the nine unusual properties shared by many cancerous cells - including the ability to recruit a blood supply. Then learn about the process of apoptosis, or programmed cell death, and the molecules being developed to block telomerase, a protein that lets cancer cells escape dying.
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As you investigate why cancer is a growing problem in the United States and across the globe, explore the burden cancer places on society as a whole - both to people and the economy - and look at some of the most common forms of the disease. See why, surprisingly, cancer doesn't rank on the Global Burden of Disease Study.
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Kick off the course with an overview of what you'll learn and the history of cancer. Discover what has transpired in the war on cancer, from the earliest theories and treatments to medicine's relatively recent transition from a focus on dividing cells to targeted therapy based on molecular biology.
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In almost all cancer, genes that stimulate cell division called oncogenes are mutated. But can one such mutation cause cancer on its own? Examine an experiment that answers this question, then look closely at proto-oncogenes and oncogenes to discover how they function and what they do in the cell to turn on cancers, including neuroblastoma tumors in children.
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Focus on cells as the basic structures of living things through an exploration of their internal composition, particularly the nucleus where the genome is retained. See how this discovery was proven in the cloning of Dolly the sheep and consider how this is relevant to cancer treatment.
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Turn to the last of the three methods of treatment with this lecture that traces the origins of chemotherapy to mustard gas attacks in World War II. Learn about the path taken by a drug on its way to a tumor, the combinations of chemotherapy used by oncologists, and how drugs are often derived from plants and other natural sources.
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Learn about molecular biology and how gene expression is controlled before turning to an investigation of the way tumor viruses use these gene control mechanisms to initiate cell division, and, ultimately, cancer. Wrap up by looking at how cancer develops in 90% of cases - from normal cells that aren't infected by viruses.
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Cancer therapies face a long road before they become viable treatment options. As you turn to the science behind surgical cancer therapy, explore this developmental process. Using breast cancer as an example, learn the scientific principles of surgical therapy and how it has evolved. Weigh the pros and cons of using surgery to diagnose cancer, remove localized tumors, and prevent metastasis.
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Two types of carcinogens mutate DNA: chemicals and radiation. Build on what you've learned about DNA by looking specifically at how these carcinogens produce cancer at the cellular level. Then, examine carcinogens that don't damage DNA and how epigenetic changes in DNA can result in cancer.
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What is the difference between benign and malignant tumors? What signs of cancer do people typically experience? Turn to tumor development and growth with a discussion of the methods doctors use to diagnose, stage, and grade tumors - all of which inform how aggressive treatment should be - and an introduction to the distressing processes of metastasis and angiogenesis.
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Some cancer drugs go to work on DNA while others target processes inside the cell. Get an introduction to both categories and learn the science behind how widely used drugs such as methotrexate, tamoxifen, and cisplatin operate. Consider the side effects patients commonly experience when undergoing chemotherapy and the reasons cells become resistant to treatment.
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Now that you understand oncogenes, focus on tumor suppressor genes. Start by learning how the BRCA1 gene mutation in inherited breast cancer was discovered - and its implications - before turning to strategies for identifying and isolating suppressor genes to be used in therapy. Explore the genes' functions, from repairing DNA damage to acting as brakes in the cell division cycle.