When Babymouse's art class goes on a field trip to the museum in the big city, she decides to test her freedom by exploring the city without a chaperone.
When Babymouse decides to become president of the student council, she learns that there is more to running for office than being famous and in charge.
Imaginative Babymouse's science partner, Felicia the cat, expects her to do all of the work for their report on microscopic creatures, but Babymouse gets help from a pizza-loving amoeba named Squish.